Article

Sarm1 Gates the Transition from Protective to Repair Schwann Cell States Following Nerve Injury

2024-07-12

Abstract excerpt

Schwann cells (SCs) transition into a Repair state after peripheral nerve injury; however, the early SC injury response preceding this transition remains poorly understood. We demonstrate that Sarm1, a key regulator of axon degeneration, is expressed and upregulated in SCs after nerve injury. Cell-type-specific Sarm1 knockout SCs exhibit enhanced axon protection in vitro , and SC- and glia-specific Sarm1 deletion...

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Literature Corpus work: afc00df5-0a32-5326-ba6d-0b086fd21452
DOI: 10.1101/2024.07.11.603162

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