Article

Senescent cells develop PDK4-dependent hypercatabolism and produce lactate to promote cancer resistance and aging

2023-01-27

Abstract excerpt

<title>Abstract</title> <p>Senescent cells remain metabolically active, but their metabolic landscape and resulting implications remain underexplored. Here we highlight upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon cellular senescence, a tendency adversely correlated with cancer patient survival after chemotherapy. Senescent cells exhibit increased aerobic glycolysis and enhanced lactate production,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 267e013e-b8b2-5f91-ab9f-edf0eaa93137
DOI: 10.21203/rs.3.rs-2485584/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Senescent cells develop PDK4-dependent hypercatabolism and produce lactate to promote cancer resistance and agingDOI 10.21203/rs.3.rs-2485584/v1Read

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistanceSemantic proximity Read

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistanceSemantic proximity Read

Metabolic reprogramming in T cell senescence: a novel strategy for cancer immunotherapySemantic proximity Read

Revisiting the biological role of the Warburg effect: Evolving perspectives on cancer metabolismSemantic proximity Read

Metabolic reprogramming: a bridge between aging and tumorigenesisSemantic proximity Read

Cell Senescence, DNA Damage, and Metabolism.Semantic proximity Read

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticitySemantic proximity Read

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesiclesSemantic proximity Read

Senescent Stroma-Derived Glutamine: A Driver of Aggressiveness in Prostate and Ovarian Cancer CellsSemantic proximity Read

Drivers of the Warburg phenotype.Semantic proximity Read

Metabolic reprogramming in cancer and senescenceSemantic proximity Read

Harnessing the interaction between redox signaling and senescence to restrain tumor drug resistanceSemantic proximity Read