Pathologic T cell immunosenescence drives the development of age-associated autoimmune peripheral neuropathy

Abstract excerpt

While certain autoimmune conditions occur commonly in the young, others are more frequent in the aged. A striking example is chronic inflammatory demyelinating polyneuropathy (CIDP), an autoimmune disease of peripheral nerves that occurs at a peak decade of onset of 70-79 years. How aging predisposes to autoimmunity, however, remains unclear. In CIDP patients, we identified an expanded population of T cells that e...

Topics

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• Aging
• Cellular Senescence
• Cytomegalovirus and herpesvirus research
• Environmental Exposure
• Environmental Pollutants
• Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• T-cell and B-cell Immunology
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

f2b079a6-b90a-5ac8-9081-2db6b60a5b30

DOI

10.64898/2026.01.07.698250