Article

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

2022-08-29

Abstract excerpt

<title>Abstract</title> <p>Cellular senescence is a state of stable growth arrest, usually accompanied by development of the senescence-associated secretory phenotype (SASP). Although senescent cells remain metabolically active, little is known about their metabolic landscape and <italic>in vivo</italic> pathophysiological implications. Here we show that expression of the pyruvate dehydrogenase (PDH) inhibitory e...

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Literature Corpus work: ce37ae53-75bb-5804-adea-f65b9d2757df
DOI: 10.21203/rs.3.rs-1966019/v1

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