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Article

Population genetics of rare variants and complex diseases.

Human heredity - 1 Jan 2012

Maher M Cyrus, Uricchio Lawrence H, Torgerson Dara G, Hernandez Ryan D

Abstract excerpt

OBJECTIVES: Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high-throughput genome sequencing technologies is a central challenge faced by human geneticists today. We hypothesize that the variants involved in complex diseases are likely to exhibit non-neutral evolutionary signatures. Uncovering the evolutionary history of all variants is therefore of intrinsic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23594490
DOI: 10.1159/000346826
PMCID: PMC3698246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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