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Article

The impact of population demography and selection on the genetic architecture of complex traits.

PLoS genetics - 1 Jan 2014

Lohmueller Kirk E

Abstract excerpt

Population genetic studies have found evidence for dramatic population growth in recent human history. It is unclear how this recent population growth, combined with the effects of negative natural selection, has affected patterns of deleterious variation, as well as the number, frequency, and effect sizes of mutations that contribute risk to complex traits. Because researchers are performing exome sequencing...

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Identifiers

PMID: 24875776
DOI: 10.1371/journal.pgen.1004379
PMCID: PMC4038606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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