Article

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOST

2024-06-20

Abstract excerpt

<title>Abstract</title> <p>A haplotype block at the sclerostin (<italic>SOST</italic>) gene correlates with bone mineral density (BMD) and increased periodontitis risk in smokers. Investigating the putative causal variants within this block, our study aimed to elucidate the impact of linked enhancer elements on gene expression and to evaluate their role in transcription factor (TF) binding. Using CRISPR/dCas9 act...

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Literature Corpus work: 508f3a3d-837b-5313-8ca6-b6bdb47a2af2
DOI: 10.21203/rs.3.rs-4409923/v1

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