Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RSPO4 is a potential risk gene of stages III-IV, grade C periodontitis through effects on innate immune response and oral barrier integrity.

Journal of clinical periodontology - 1 Apr 2023

Chopra Avneesh, Song Jiahui, Weiner January, Keceli Huseyin G, Dincer Pervin R, Cruz Raquel, Carracedo Angel, Blanco Juan, Dommisch Henrik, Schaefer Arne S

Abstract excerpt

AIM: R-spondin 4 (RSPO4) is a suggestive risk gene of stage III-IV, grade C periodontitis and upregulated in gingiva of mice resistant to bacteria-induced alveolar bone loss. We aimed to replicate the association, identify and characterize the putative causal variant(s) and molecular effects, and understand the downstream effects of RSPO4 upregulation. MATERIALS AND METHODS: We performed a two-step association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alveolar Bone Loss
Share to Cell Adhesion Molecules, Neuronal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Immunity, Innate

Share to Periodontitis

Source

Identifiers

PMID: 36507580
DOI: 10.1111/jcpe.13758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RSPO4 is a potential risk gene of stages III-IV, grade C periodontitis through effects on innate immune response and oral barrier integrity.PMID 36507580Read ↗

Genome-wide association study of stage III/IV grade C periodontitis (former aggressive periodontitis) in a Spanish population.Semantic proximity Read ↗

A genome-wide association study meta-analysis in a European sample of stage III/IV grade C periodontitis patients ≤35 years of age identifies new risk loci.Semantic proximity Read ↗

Genetic Susceptibility to PeriodontitisSemantic proximity Read ↗

Combined periodontitis GWAS identifies LINC01541 as a regulator of innate immunity in the oral mucosa.Semantic proximity Read ↗

Mendelian randomized integration of GEO and eQTL data revealed genes associated with periodontitisSemantic proximity Read ↗

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOSTSemantic proximity Read ↗

A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.Semantic proximity Read ↗

Shared Genotypic Architectures of Stage III/IV Grade C Periodontitis Under 35 Years of Age (Former Aggressive Periodontitis) and Abnormal Root Morphology: A Family-Based Study.Semantic proximity Read ↗

The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.Semantic proximity Read ↗

Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology.Semantic proximity Read ↗

Multi-Omics Integration Reveals the Genetic Mechanisms of Periodontitis and Predicts Therapeutic Drugs.Semantic proximity Read ↗

Expression of periodontitis susceptibility genes in human gingiva using single-cell RNA sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.