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Article

Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis.

Bone - 1 Mar 2018

Ye Weiyuan, Wang Ya, Mei Bing, Hou Sasa, Liu Xinhong, Wu Guiju, Qin Longjuan, Zhao Kehui, Huang Qingyang

Abstract excerpt

The SOST gene encodes sclerostin, a C-terminal cysteine knot-like domain containing key negative regulator of osteoblastic bone formation that inhibits LRP5/6-mediated canonical Wnt signaling. Numerous single nucleotide polymorphisms (SNPs) in the SOST locus are firmly associated with bone mineral density (BMD) and fracture in genome-wide association studies (GWAS) and candidate gene association studies. However,...

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Source

Identifiers

PMID: 29307778
DOI: 10.1016/j.bone.2018.01.001

Genes

SOST
CTCF
FOXA1
LRP5
MAFF
MAFK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis.PMID 29307778Read ↗

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