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Article

Control of the <i>SOST</i> Bone Enhancer by PTH Using MEF2 Transcription Factors

13 Aug 2007

Abstract excerpt

UNLABELLED: Expression of the osteocyte-derived bone formation inhibitor sclerostin in adult bone requires a distant enhancer. We show that MEF2 transcription factors control this enhancer and mediate inhibition of sclerostin expression by PTH. INTRODUCTION: Sclerostin encoded by the SOST gene is a key regulator of bone formation. Lack of SOST expression is the cause for the progressive bone overgrowth disorders...

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Identifiers

PMID: 17696759
DOI: 10.1359/jbmr.070804

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Research trail→

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Control of the <i>SOST</i> Bone Enhancer by PTH Using MEF2 Transcription FactorsPMID 17696759Read ↗

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.Semantic proximity Read ↗

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Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOSTSemantic proximity Read ↗

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