Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis.

Bone - 1 Aug 2009

Huang Qing-Yang, Li Gloria H Y, Kung Annie W C

Abstract excerpt

Accumulating evidence shows that genes that cause monogenic diseases also contribute to similar complex disease in the general population. We sought to determine whether the allelic variation in seven monogenic bone disease genes (CLCN7, TCIRGI, SOST, CA2, CSTK, TGFB1 and SLC26A2) contributes to osteoporosis/bone mineral density (BMD) variation in the normal Chinese population. We conducted a gene-wide tag...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Protein-alpha

Share to Computational Biology

Share to Genetic Markers

Share to Hepatocyte Nuclear Factor 3-alpha

Share to Osteoporosis

Share to Regulatory Sequences, Nucleic Acid

Source

Identifiers

PMID: 19371798
DOI: 10.1016/j.bone.2009.03.676

Genes

FOXA1
SOST
CLCN7
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis.PMID 19371798Read ↗

Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis.Semantic proximity Read ↗

Eight genes are highly associated with BMD variation in postmenopausal Caucasian women.Semantic proximity Read ↗

Contribution of the sclerostin domain-containing protein 1 (SOSTDC1) gene to normal variation of peak bone mineral density in Chinese women and men.Semantic proximity Read ↗

Differential gene expression orchestrated by transcription factors in osteoporosis: bioinformatics analysis of associated polymorphism elaborating functional relationships.Semantic proximity Read ↗

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOSTSemantic proximity Read ↗

The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.Semantic proximity Read ↗

Integrating genome-wide association and transcriptome predicted model identify novel target genes with osteoporosisSemantic proximity Read ↗

An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation.Semantic proximity Read ↗

The osteoporosis risk variant rs9820407 at 3p22.1 acts as an allele-specific enhancer to regulate CTNNB1 expression by long-range chromatin loop formation.Semantic proximity Read ↗

Relationship between rs7586085, GALNT3 and CCDC170 gene polymorphisms and the risk of osteoporosis among the Chinese Han population.Semantic proximity Read ↗

Metaanalysis Reveals Genetic Correlates of Osteoporosis PathogenesisSemantic proximity Read ↗

Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.