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Article

Cbfa1/RUNX2 Directs Specific Expression of the Sclerosteosis Gene (SOST)

26 Mar 2004

Abstract excerpt

Loss-of-function mutations in the sclerosteosis gene (SOST) cause a rare sclerosing bone dysplasia characterized by skeletal overgrowth. Cbfa1/RUNX2 is a key transcriptional regulator of osteoblast function. Here we link these two pathways by demonstrating, via gel shift and transient transfection analyses, that Cbfa1 binding to the proximal SOST promoter contributes to differential SOST expression in two...

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PMID: 14739291
DOI: 10.1074/jbc.m306249200

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