Article
Combined periodontitis GWAS identifies LINC01541 as a regulator of innate immunity in the oral mucosa.
Human molecular genetics - 26 May 2026
Richter Gesa M, Akinloye Oluwabukunmi M, Kühnlenz Tim, Weiner January Rd, Holtfreter Birte, de Coo Alicia, Diz-De Almeida Silvia, Loos Bruno G, Jepsen Søren, Dommisch Henrik, Bruckmann Corinna, Kapferer-Seebacher Ines, Homuth Georg, Kocher Thomas, Völzke Henry, Berger Klaus, Laudes Matthias, Lieb Wolfgang, van der Velde Nathalie, van Schoor Natasja M, de Groot Lisette, Blanco Juan, Carracedo Angel, Cruz Raquel, Dempfle Astrid, Teumer Alexander, Freitag-Wolf Sandra, Schaefer Arne S
Abstract excerpt
Periodontitis is a complex inflammatory disease in which chronic immune activation drives destruction of periodontal soft tissues and alveolar bone. Although early-onset forms show high heritability, much genetic risk remains unresolved. To identify shared genetic signals across early- and later-onset periodontitis, we combined two European genome-wide association study datasets (3183 cases, 10 326 controls) and...
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