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Article

SNP-adjacent super enhancer network mediates enhanced osteogenic differentiation of MSCs in ankylosing spondylitis.

Human molecular genetics - 26 Apr 2021

Yu Wenhui, Chen Keng, Ye Guiwen, Wang Shan, Wang Peng, Li Jinteng, Zheng Guan, Liu Wenjie, Lin Jiajie, Su Zepeng, Che Yunshu, Ye Feng, Ma Mengjun, Xie Zhongyu, Shen Huiyong

Abstract excerpt

Ankylosing spondylitis (AS) is a rheumatic disease with pathological osteogenesis that causes bony ankylosis and even deformity over time. Mesenchymal stem cells (MSCs) are multipotent stem cells that are the main source of osteoblasts. We previously demonstrated that enhanced osteogenic differentiation of MSCs from AS patients (ASMSCs) is related to pathological osteogenesis in AS. However, the more concrete...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33355648
DOI: 10.1093/hmg/ddaa272

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