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Article

Cell size and growth rate are major determinants of replicative lifespan.

Cell cycle (Georgetown, Tex.) - 1 Jan 2011

Yang Jingye, Dungrawala Huzefa, Hua Hui, Manukyan Arkadi, Abraham Lesley, Lane Wesley, Mead Holly, Wright Jill, Schneider Brandt L

Abstract excerpt

Yeast cells, like mammalian cells, enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of the relationship between size and cellular lifespan is not well understood. Herein, we report a genetic link between cell size, growth rate and lifespan. Mutations that increase cell size concomitantly increase growth rate and decrease lifespan. As a result, large...

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Identifiers

PMID: 21248481
DOI: 10.4161/cc.10.1.14455
PMCID: PMC3048081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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