Article

Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian Cancer

2023-02-20

Abstract excerpt

<h4>Background: </h4> High-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and somatic genetic alterations in HGSC and their association with relapse-free and overall survival. Using a targeted capture of 577 genes involved in DNA damage response and PI3K/AKT/mTOR pathways, we conducted next-generation sequencing of DNA from matched b...

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Literature Corpus work: 505cb2f5-5be6-5135-862f-aeafd2739ab5
DOI: 10.21203/rs.3.rs-2592107/v1

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