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Article

Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals.

Cancer research - 2 May 2025

Lawson-Michod Katherine A, Marks Jeffrey R, Collin Lindsay J, Nix David A, Davidson Natalie R, Huff Chad D, Yu Yao, Atkinson Aaron, Johnson Courtney E, Salas Lucas A, Peres Lauren C, Greene Casey S, Schildkraut Joellen M, Doherty Jennifer A

Abstract excerpt

Black individuals experience worse survival after a diagnosis of high-grade serous ovarian carcinoma (HGSC) than White individuals and are underrepresented in ovarian cancer research. To date, the understanding of the molecular and genomic heterogeneity of HGSC is based primarily on the evaluation of tumors from White individuals. In the present study, we performed whole-exome sequencing on HGSC samples from 211...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40063699
DOI: 10.1158/0008-5472.CAN-24-1879
PMCID: PMC12048278

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KRAS
OBSCN

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