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Article

Comprehensive Germline Profiling of High-Grade Serous Ovarian Cancer Using Whole-Exome Sequencing.

International journal of molecular sciences - 19 Jun 2026

Cho Hye-Lim, Bak Seong Eun, Han Mi-Ryung, Choi Youn Jin

Abstract excerpt

While ovarian cancer screening is not recommended in the general population, attention has shifted to screening women with elevated hereditary risks. Although germline BRCA 1/2 pathogenic variants account for 40% of inherited ovarian cancer risk and family history (FH) remains important, known germline variants alone do not fully explain familial ovarian cancer risk. Whole-exome sequencing (WES) was performed on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42353278
DOI: 10.3390/ijms27125564
PMCID: PMC13299865

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FH

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