Article
Comprehensive next-generation sequencing identifies novel putative pathogenic or likely pathogenic germline variants in patients with concurrent tubo-ovarian and endometrial serous and endometrioid carcinomas or precursors.
Gynecologic oncology - 1 Aug 2024
Aisagbonhi Omonigho, Ghlichloo Ida, Hong Duncan S, Roma Andres, Fadare Oluwole, Eskander Ramez, Saenz Cheryl, Fisch Kathleen M, Song Wei
Abstract excerpt
BACKGROUND: Endometrial serous carcinoma (ESC) and tubo-ovarian high-grade serous carcinoma (HGSC) are characterized by late-stage presentation and high mortality. Current guidelines for prevention recommend risk-reducing salpingo-oophorectomy (RRSO) in patients with hereditary mutations in cancer susceptibility genes. However, HGSC displays extensive genetic heterogeneity with alterations in 168 genes identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.