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Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer

17 Jul 2023

Abstract excerpt

BACKGROUND: High-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and somatic genetic alterations in HGSC and their association with relapse-free and overall survival. Using a targeted capture of 557 genes involved in DNA damage response and PI3K/AKT/mTOR pathways, we conducted next-generation sequencing of DNA from matched blood and...

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Cancer Genomics and Diagnostics
DNA Repair Mechanisms
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37460928
DOI: 10.1186/s13048-023-01234-x

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