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Article

High-Grade Serous Ovarian Carcinoma in the Genomics Era: Current Applications, Challenges and Future Directions.

International journal of molecular sciences - 6 Feb 2026

Lewis Molly Elizabeth, Caricato Chiara, Roberts Hannah Leigh, Ganesan Subhasheenee, Seksaf Nadia Amel, Maniati Eleni, Sideris Michail

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is characterised by profound genomic instability and limited durable responses to standard therapy, leading to poor prognosis. The use of next-generation sequencing technologies has improved understanding of its molecular landscape, revealing consistent Tumour Protein p53 (TP53) mutations, homologous recombination defects, pathway alterations, and epigenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41684035
DOI: 10.3390/ijms27031617
PMCID: PMC12898509

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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