Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma.

doi:10.1158/1078-0432.CCR-20-4068

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2021

Ewing Ailith, Meynert Alison, Churchman Michael, Grimes Graeme R, Hollis Robert L, Herrington C Simon, Rye Tzyvia, Bartos Clare, Croy Ian, Ferguson Michelle, Lennie Mairi, McGoldrick Trevor, McPhail Neil, Siddiqui Nadeem, Dowson Suzanne, Glasspool Rosalind, Mackean Melanie, Nussey Fiona, McDade Brian, Ennis Darren, McMahon Lynn, Matakidou Athena, Dougherty Brian, March Ruth, Barrett J Carl, McNeish Iain A, Biankin Andrew V, Roxburgh Patricia, Gourley Charlie, Semple Colin A

Abstract excerpt

PURPOSE: The abundance and effects of structural variation at BRCA1/2 in tumors are not well understood. In particular, the impact of these events on homologous recombination repair deficiency (HRD) has yet to be demonstrated. EXPERIMENTAL DESIGN: Exploiting a large collection of whole-genome sequencing data from high-grade serous ovarian carcinoma (N = 205) together with matched RNA sequencing for the majority...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Cystadenocarcinoma, Serous

Share to Gene Expression

Share to Homologous Recombination

Share to Ovarian Neoplasms

Share to Recombinational DNA Repair

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 33741650
DOI: 10.1158/1078-0432.CCR-20-4068
PMCID: PMC7610896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma.PMID 33741650Read ↗

Structural variants at the <i>BRCA1/2</i> loci are a common source of homologous repair deficiency in high grade serous ovarian carcinomaSemantic proximity Read ↗

Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian CancerSemantic proximity Read ↗

Genomic analyses of germline and somatic variation in high-grade serous ovarian cancerSemantic proximity Read ↗

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancerSemantic proximity Read ↗

Small-scale variants and large deletions in BRCA1/2 genes in Slovak high-grade serous ovarian cancer.Semantic proximity Read ↗

Decoding the Genomic and Functional Landscape of Emerging Subtypes in Ovarian CancerSemantic proximity Read ↗

TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer.Semantic proximity Read ↗

Optimized detection of allelic imbalances specific for homologous recombination deficiency improves the prediction of clinical outcomes in cancerSemantic proximity Read ↗

Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancerSemantic proximity Read ↗

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.Semantic proximity Read ↗

Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival.Semantic proximity Read ↗

Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.