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Article

Genomic alterations linked to recurrence risk in high-grade serous ovarian cancer revealed by deep targeted sequencing.

Scientific reports - 18 Dec 2025

Park Young-Hoon, Park Seong-Woo, Kim Jee-Whan, Lee Yoo-Kyung, Cho Hanbyoul, Park In-Ho, Han Mi-Ryung, Kim Jae-Hoon

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) is a highly fatal disease with frequent recurrence and high mortality rates, despite ongoing treatment advancements. Next-generation sequencing (NGS) is an experimental technique used to obtain extensive genetic information, making it a key component of precision medicine. We conducted a study based on a sample of 108 patients with HGSOC retrospectively selected from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41413429
DOI: 10.1038/s41598-025-26481-4
PMCID: PMC12717093

Genes

NF1
ROS1
FAT1
NOTCH3
ARID1A
ATM
BLM
SLX4

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Genomic alterations linked to recurrence risk in high-grade serous ovarian cancer revealed by deep targeted sequencing.PMID 41413429Read ↗

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