Article

Accelerated brain aging towards transcriptional inversion in a zebrafish model of familial Alzheimer’s disease

2018-02-09

Abstract excerpt

Alzheimer’s disease (AD) develops silently over decades. We cannot easily access and analyse pre-symptomatic brains, so the earliest molecular changes that initiate AD remain unclear. Previously, we demonstrated that the genes mutated in early-onset, dominantly-inherited familial forms of AD (fAD) are evolving particularly rapidly in mice and rats. Fortunately, some non-mammalian vertebrates such as the zebrafish...

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Literature Corpus work: fba53aeb-91b5-556f-991a-92ca2c643b00
DOI: 10.1101/262162

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