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Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in <i>psen1</i> indicate effects on oxidative phosphorylation, mcm functions, and iron homeostasis

2020-05-05

Abstract excerpt

Early-onset familial Alzheimer’s disease (EOfAD) is promoted by dominant mutations, enabling the study of Alzheimer’s disease (AD) pathogenic mechanisms through generation of EOfAD-like mutations in animal models. In a previous study, we generated an EOfAD-like mutation, psen1 Q96_K97del , in zebrafish and performed a transcriptome analysis comparing entire brains from 6-month-old wild type and heterozygous mutan...

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Literature Corpus work
6f5ce645-bdfd-5f8c-9008-52b2a9898dc9
DOI
10.1101/2020.05.03.075424
Open publication

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Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in <i>psen1</i> indicate effects on oxidative phosphorylation, mcm functions, and iron homeostasisDOI 10.1101/2020.05.03.075424
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