Article

Co-chaperone-mediated post-translational control of efflux pump induction underlies adaptive β-lactam resistance in <i>Caulobacter crescentus</i>

2023-02-20

Abstract excerpt

<h4>SUMMARY</h4> The acquisition of multi-drug resistance (MDR) determinants jeopardizes treatment of bacterial infections with antibiotics. The tripartite efflux pump AcrAB-NodT confers adaptive MDR in the non-pathogenic α-proteobacterium Caulobacter crescentus via transcriptional induction by first-generation quinolone antibiotics. We discovered that overexpression of AcrAB-NodT by mutation or exogenous induce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5045d959-01c5-5eee-a328-a0df983bf9c5
DOI: 10.1101/2023.02.20.529182

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Co-chaperone-mediated post-translational control of efflux pump induction underlies adaptive β-lactam resistance in <i>Caulobacter crescentus</i>DOI 10.1101/2023.02.20.529182Read

Beyond mecA: a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA.Semantic proximity Read

Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosisSemantic proximity Read

Mutational Activation of Antibiotic-Resistant Mechanisms in the Absence of Major Drug Efflux Systems of Escherichia coli.Semantic proximity Read

Drugging evolution of antibiotic resistance at a regulatory network hub.Semantic proximity Read

Phenotypic and multi-omics characterization of <i>Escherichia coli</i> K-12 adapted to quaternary ammonium compounds identifies lipid A and cell envelope alterations regulated by mar-sox-rob and stress inducible pathwaysSemantic proximity Read

Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacteriumSemantic proximity Read

Envelope destabilization by AcrAB2NodT overexpression links antibiotic resistance to metal sensitivity in Caulobacter vibrioides.Semantic proximity Read

Tuberculosis treatment failure associated with evolution of antibiotic resilienceSemantic proximity Read

A small molecule that inhibits the evolution of antibiotic resistanceSemantic proximity Read

Elucidating TolC Protein Dynamics: Structural Shifts Facilitate Efflux Mediated β-lactam ResistanceSemantic proximity Read

An epigenetic mechanism of azole tolerance facilitates acquired antifungal resistance in <i>Aspergillus fumigatus</i>Semantic proximity Read

Tripartite efflux pumps of the RND superfamily: what did we learn from computational studies?Semantic proximity Read