Article

Elucidating TolC Protein Dynamics: Structural Shifts Facilitate Efflux Mediated β-lactam Resistance

2024-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Efflux-mediated β-lactam resistance represents a significant public health challenge, limiting the efficacy of various β-lactam antibiotics against numerous clinically relevant pathogenic bacteria. Structural and functional analyses have revealed that the efflux protein TolC in several Gram-negative bacteria serves as a conduit for antibiotics, bacteriocins, and phages, affecting bacterial susce...

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Literature Corpus work: 7871987f-9722-5e7d-ad3a-8191fd81517a
DOI: 10.1101/2024.02.22.581573

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