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Article

Envelope destabilization by AcrAB2NodT overexpression links antibiotic resistance to metal sensitivity in Caulobacter vibrioides.

Communications biology - 23 Jan 2026

Ote Marine, Lardinois Lorine, Hendrickx Erika, Dieu Marc, Jurėnas Dukas, Matroule Jean-Yves

Abstract excerpt

Antibiotic (AB) resistance often arises through mutations that alter AB targets, reduce membrane permeability, or increase efflux activity, yet its physiological costs remain poorly understood. In Caulobacter vibrioides, a ΔtipR mutant that constitutively upregulates the RND efflux pump AcrAB2NodT exhibits heightened sensitivity to copper (Cu), revealing a trade-off linked to excessive pump expression. Deleting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41577953
DOI: 10.1038/s42003-026-09606-x
PMCID: PMC12932660

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