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Article

Beyond mecA: a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA.

Antimicrobial agents and chemotherapy - 4 Feb 2026

Sassman Melissa, Karolak Michele, Dallaire Margeurite, Schaffer Claire E, Gartner Carlos, Vary Calvin, Rosato Roberto R, Rosato Adriana E

Abstract excerpt

High-level resistance to ceftaroline, a fifth-generation β-lactam critical for treating methicillin-resistant Staphylococcus aureus (MRSA), is an emerging threat to global health. While resistance is traditionally attributed to mecA-mediated expression of PBP2a, our study reveals a previously unrecognized mechanism. We show that high-level resistance to ceftaroline can arise independently of ceftaroline exposure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41498550
DOI: 10.1128/aac.00586-25
PMCID: PMC12888875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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