Back to search

Article

Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium

2022-11-01

Abstract excerpt

The cell envelope of the Gram-negative Burkholderia cepacia complex (Bcc) presents unique restrictions to antibiotic penetration. As a consequence, Bcc species are notorious for causing recalcitrant multidrug-resistant infections in immunocompromised individuals, such as those living with cystic fibrosis. To systematically identify cell envelope-associated resistance and susceptibility determinants at the genome...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
343fee23-3777-5ac3-af27-f2a9d18fab40
DOI
10.1101/2022.11.01.510852
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacteriumDOI 10.1101/2022.11.01.510852
Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacteriumSemantic proximity
Genetic basis of cefiderocol resistance in Acinetobacter baumannii: insights from functional genomics and clinical isolates.Semantic proximity
Beyond mecA: a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA.Semantic proximity
The fitness cost of metallo-β-lactamase expression is a potential target for new therapeutic approaches to carbapenem resistanceSemantic proximity
A genome-wide atlas of antibiotic susceptibility targets and pathways to toleranceSemantic proximity
<i>Burkholderia cepacia</i>Complex: Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and DeterminantsSemantic proximity
Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A ReviewSemantic proximity
Genomics and structural insight into the masking of gentamicin-resistance in clinical Burkholderia pseudomallei strain VB29710 from India.Semantic proximity
Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA β-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis PathogenSemantic proximity
Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in <i>Pseudomonas aeruginosa</i> clinical isolatesSemantic proximity
Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related speciesSemantic proximity
Loss of β-ketoacyl acyl carrier protein synthase III activity restores multidrug-resistant <i>Escherichia coli</i> sensitivity to previously ineffective antibioticsSemantic proximity
Select a neighboring publication to make it the new centre.