Article

Adaptive Plasticity Tumor Cells Modulate MAPK-Targeting Therapy Response in Colorectal Cancer

2025-01-24

Abstract excerpt

MAPK pathway inhibitors (MAPKi) are increasingly used in the treatment of advanced colorectal cancer, but often produce short-lived responses in patients. Although acquired resistance by de novo mutations in tumors have been found to reduce response in some patients, additional mechanisms underlying the limited response durability of MAPK targeting therapy remain unknown. Here, we denote new contributory tumor bi...

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Literature Corpus work: 88d0a8fc-6c71-5124-af8a-27505e16f34d
DOI: 10.1101/2025.01.22.634215

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