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Article

Bridging sequence-structure motifs and genetic variants for genome-wide dynamic RNA-protein interaction profiling.

Nature communications - 15 May 2026

Wang Yubo, Zhu Haoran, Hao Gaoyang, Su Yanchi, Yu Zhuohan, Yang Yuning, Wang Fuzhou, Chen Xingjian, Wong Ka-Chun, Li Xiangtao

Abstract excerpt

RNA-binding proteins (RBPs) often recognize complex RNA secondary structure motifs, and these interactions can vary between cell lines. However, no current computational model can explain the dynamic behavior of RNA sequence-structure motifs across multiple cell lines and link these dynamics to the functional impact of genetic variation. Here we show BRIDGE, an end-to-end unified model that bridges...

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Identifiers

PMID: 42140941
DOI: 10.1038/s41467-026-73086-0
PMCID: PMC13376783

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