Article

Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes

2020-08-27

Abstract excerpt

Human cancers can exhibit phenotype switching, resulting in cells that are more metastatic or that are more tolerant to treatment. However, the relationship between these aggressive states is not well understood. We investigated the dynamics of phenotypic switching in human melanoma cells by monitoring the fluorescent activity from a transgenic reporter of BRN2 promoter activation. Melanoma cells exhibit heterogen...

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Literature Corpus work: 500e77d9-9b7f-5828-90df-223a994922d2
DOI: 10.1101/2020.08.26.269126

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