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Article

<i>In vivo</i> Switching of Human Melanoma Cells between Proliferative and Invasive States

1 Feb 2008

Abstract excerpt

Metastatic melanoma represents a complex and heterogeneous disease for which there are no therapies to improve patient survival. Recent expression profiling of melanoma cell lines identified two transcription signatures, respectively, corresponding with proliferative and invasive cellular phenotypes. A model derived from these findings predicts that in vivo melanoma cells may switch between these states. Here,...

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PMID: 18245463
DOI: 10.1158/0008-5472.can-07-2491

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