Article
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma.
Nature cell biology - 1 Aug 2020
Wouters Jasper, Kalender-Atak Zeynep, Minnoye Liesbeth, Spanier Katina I, De Waegeneer Maxime, Bravo González-Blas Carmen, Mauduit David, Davie Kristofer, Hulselmans Gert, Najem Ahmad, Dewaele Michael, Pedri Dennis, Rambow Florian, Makhzami Samira, Christiaens Valerie, Ceyssens Frederik, Ghanem Ghanem, Marine Jean-Christophe, Poovathingal Suresh, Aerts Stein
Abstract excerpt
Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered evidence indicates that additional intermediate state(s) may exist. Here, to search for such states and decipher their underlying gene regulatory network (GRN), we studied 10 melanoma cultures using single-cell RNA sequencing (RNA-seq) as well as 26 additional cultures using bulk RNA-seq. Although each culture exhibited a...
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