Article
The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report.
Melanoma research - 1 Aug 2010
Eichhoff Ossia M, Zipser Marie C, Xu Mai, Weeraratna Ashani T, Mihic Daniela, Dummer Reinhard, Hoek Keith S
Abstract excerpt
To date there is no effective therapy for metastatic melanoma and at the molecular level the disease progression is poorly understood. A recent study by our group led to the development of a novel phenotype switching model for melanoma progression, wherein cells transition back-and-forth between states of proliferation and invasion to drive disease progression. To explore the model's clinical relevance we...
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