Article

Cryptic β-lactamase evolution is driven by low β-lactam concentrations

2020-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Our current understanding of how low antibiotic concentrations shape the evolution of contemporary β-lactamases is limited. Using the wide-spread carbapenemase OXA-48, we tested the long-standing hypothesis that selective compartments with low antibiotic concentrations cause standing genetic diversity that could act as a gateway to develop clinical resistance. Here, we subjected Escherichia col...

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Literature Corpus work: 4ff84903-b822-5815-96a4-a6af716b8b15
DOI: 10.1101/2020.12.01.404343

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