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Article

Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations.

mSphere - 28 Apr 2021

Fröhlich Christopher, Gama João A, Harms Klaus, Hirvonen Viivi H A, Lund Bjarte A, van der Kamp Marc W, Johnsen Pål J, Samuelsen Ørjan, Leiros Hanna-Kirsti S

Abstract excerpt

Our current understanding of how low antibiotic concentrations shape the evolution of contemporary β-lactamases is limited. Using the widespread carbapenemase OXA-48, we tested the long-standing hypothesis that selective compartments with low antibiotic concentrations cause standing genetic diversity that could act as a gateway to developing clinical resistance. Here, we subjected Escherichia coli expressing...

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Identifiers

PMID: 33910990
DOI: 10.1128/mSphere.00108-21
PMCID: PMC8092134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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