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Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens

2025-01-24

Abstract excerpt

Conjugative plasmids are the main vehicle for the spread of antimicrobial resistance (AMR) genes in clinical bacteria. AMR plasmids allow bacteria to survive antibiotic treatments, but they also produce physiological alterations in their hosts that commonly translate into fitness costs. Despite the key role of plasmid-associated fitness effects in AMR evolution, their origin and molecular bases remain poorly under...

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Identifiers and source

Literature Corpus work
96d6b92a-bba9-546f-9cad-e16b4f5f7be7
DOI
10.1101/2025.01.23.633114
Open publication

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Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screensDOI 10.1101/2025.01.23.633114
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