Article

Adaptive landscape of the metallo-β-lactamase NDM to emerging β-lactam-based therapies

2026-07-13

Abstract excerpt

The New Delhi metallo-β-lactamase (NDM) is a major determinant of carbapenem resistance. This has prompted the development of novel therapeutic strategies to treat NDM producers. Since these therapies impose new selective pressures, their clinical deployment may favor NDM variants carrying escape mutations. To anticipate these events and inform future therapeutic decisions, we explored the evolutionary landscape o...

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Literature Corpus work: 1d0efa2f-95cc-5c28-b0b3-95e61b918457
DOI: 10.64898/2026.07.10.737697

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