Cryptic phenotypic variation emerges rapidly during the adaptive evolution of a carbapenemase.

Abstract excerpt

Interactions among beneficial mutations (that is, epistasis) are often strong enough to direct adaptation through alternative mutational paths. Although alternative solutions should display similar fitness under the primary selective conditions, their properties across secondary environments may differ widely. The extent to which these cryptic differences are to be expected is largely unknown, despite their...

Topics

• beta-Lactamases
• Bacterial Proteins
• Klebsiella pneumoniae
• Ceftazidime
• Phenotype
• Evolution, Molecular
• Anti-Bacterial Agents
• Epistasis, Genetic
• Directed Molecular Evolution
• Mutation