Article

Genomic determinants of protein abundance variation in colorectal cancer cells

2016-12-09

Abstract excerpt

<h4>Summary</h4> Assessing the extent to which genomic alterations compromise the integrity of the proteome is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling and tribrid mass spectrometry to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the relationships between genomic and proteomic variation. The robust quanti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4fc01b5c-4c02-5091-b994-e14ece998e18
DOI: 10.1101/092767

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic determinants of protein abundance variation in colorectal cancer cellsDOI 10.1101/092767Read

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.Semantic proximity Read

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.Semantic proximity Read

Pan-cancer proteomic map of 949 human cell lines reveals principles of cancer vulnerabilitiesSemantic proximity Read

Beyond the genome and proteome: targeting protein modifications in cancerSemantic proximity Read

Multi-omics characterization of interaction-mediated control of human protein abundance levelsSemantic proximity Read

Interpretation of cancer mutations using a multiscale map of protein systems.Semantic proximity Read

Panomics reveals patient-individuality as the major driver for colorectal cancer progressionSemantic proximity Read

Proteome Heterogeneity in Colorectal Cancer.Semantic proximity Read

Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch RepairSemantic proximity Read

Integrating Serum Proteomics with Tissue Multi-Omics Data Identifies TOP2A as a Key Molecule in Colorectal CancerSemantic proximity Read

Tissue Proteomic Signatures of BRAF-Mutated Colorectal Cancer Reveal New Insights into Aggressiveness, Immune Modulation, and Metabolic Reprogramming.Semantic proximity Read

Stage‐specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesisSemantic proximity Read