Article

Integrating Serum Proteomics with Tissue Multi-Omics Data Identifies TOP2A as a Key Molecule in Colorectal Cancer

2026-06-10

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with a rising incidence among younger adults. Current diagnostic biomarkers lack sufficient sensitivity and specificity, highlighting an urgent need for novel biomarkers. Methods We integrated serum proteomic data from 16 CRC patients and 8 healthy controls with tissue multi-omics data fr...

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Literature Corpus work: d2318cf2-68a9-52b7-a993-22d27e1e293c
DOI: 10.21203/rs.3.rs-9541546/v1

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