Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.

doi:10.1053/j.gastro.2017.06.008

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Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.

Gastroenterology - 1 Oct 2017

Wang Jing, Mouradov Dmitri, Wang Xiaojing, Jorissen Robert N, Chambers Matthew C, Zimmerman Lisa J, Vasaikar Suhas, Love Christopher G, Li Shan, Lowes Kym, Leuchowius Karl-Johan, Jousset Helene, Weinstock Janet, Yau Christopher, Mariadason John, Shi Zhiao, Ban Yuguang, Chen Xi, Coffey Robert J C, Slebos Robbert J C, Burgess Antony W, Liebler Daniel C, Zhang Bing, Sieber Oliver M

Abstract excerpt

BACKGROUND AND AIMS: Proteomics holds promise for individualizing cancer treatment. We analyzed to what extent the proteomic landscape of human colorectal cancer (CRC) is maintained in established CRC cell lines and the utility of proteomics for predicting therapeutic responses. METHODS: Proteomic and transcriptomic analyses were performed on 44 CRC cell lines, compared against primary CRCs (n=95) and normal...

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Identifiers

PMID: 28625833
DOI: 10.1053/j.gastro.2017.06.008
PMCID: PMC5623120

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