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Article

Tissue Proteomic Signatures of BRAF-Mutated Colorectal Cancer Reveal New Insights into Aggressiveness, Immune Modulation, and Metabolic Reprogramming.

Journal of proteome research - 7 Aug 2026

Miolo Gianmaria, Marus Wally, Canil Giovanni, Inversi Amy, Puglisi Fabio, Corona Giuseppe

Abstract excerpt

Colorectal cancer (CRC) is characterized by molecular heterogeneity, with BRAF-mutated tumors being particularly aggressive and refractory to standard therapies. This study aimed to identify distinctive proteomic signatures associated with the BRAF V600E mutation through comparative tumor tissue profiling. Thirty-three tumor tissues were analyzed: 9 BRAF-mutated, 14 RAS-mutated, and 10 wild-type (WT). Proteomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 42366749
DOI: 10.1021/acs.jproteome.6c00178

Genes

BRAF
AHSA1
DPP4
LPCAT1
QPRT
TXNDC5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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