Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

doi:10.1016/j.celrep.2017.08.010

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Article

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

Cell reports - 29 Aug 2017

Roumeliotis Theodoros I, Williams Steven P, Gonçalves Emanuel, Alsinet Clara, Del Castillo Velasco-Herrera Martin, Aben Nanne, Ghavidel Fatemeh Zamanzad, Michaut Magali, Schubert Michael, Price Stacey, Wright James C, Yu Lu, Yang Mi, Dienstmann Rodrigo, Guinney Justin, Beltrao Pedro, Brazma Alvis, Pardo Mercedes, Stegle Oliver, Adams David J, Wessels Lodewyk, Saez-Rodriguez Julio, McDermott Ultan, Choudhary Jyoti S

Abstract excerpt

Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of somatic genomic variants. The robust quantification of over 9,000 proteins and 11,000 phosphopeptides on average enabled...

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Identifiers

PMID: 28854368
DOI: 10.1016/j.celrep.2017.08.010
PMCID: PMC5583477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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