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Stage‐specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis

16 Oct 2006

Abstract excerpt

To identify sequential alterations of the genome, transcriptome, and proteome during colorectal cancer progression, we have analyzed tissue samples from 36 patients, including the complete mucosa-adenoma-carcinoma sequence from 8 patients. Comparative genomic hybridization (CGH) revealed patterns of stage specific, recurrent genomic imbalances. Gene expression analysis on 9K cDNA arrays identified 58 genes...

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PMID: 17044061
DOI: 10.1002/gcc.20382

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