Pan-cancer proteomic map of 949 human cell lines reveals principles of cancer vulnerabilities

Abstract excerpt

<h4>Summary</h4> The proteome provides unique insights into biology and disease beyond the genome and transcriptome. Lack of large proteomic datasets has restricted identification of new cancer biomarkers. Here, proteomes of 949 cancer cell lines across 28 tissue types were analyzed by mass spectrometry. Deploying a clinically-relevant workflow to quantify 8,498 proteins, these data capture evidence of cell type...

Topics

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• Cancer Genomics and Diagnostics
• Cell Line, Tumor
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Glycosylation and Glycoproteins Research
• Neoplasms
• Peptidase Inhibition and Analysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

ac2773fd-773e-5e61-97c1-bd1a0701e500

DOI

10.1101/2022.02.26.482008