Article

Novel insights into in vivo functions of the asthma susceptibility gene ORMDL3

2017-01-01

Abstract excerpt

ORMDL3 was first identified as an asthma susceptibility gene by multiple GWA studies. Subsequent in vitro and in vivo analyses identified the protein as a negative regulator of de novo sphingolipid synthesis and inducer of ER-stress, while ORMDL3 overexpression in mice elevated IgE, eosinophilia and IL-4 induction in response to OVA application. The aim of this thesis was to decipher functions of ORMDL3 in regulat...

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Literature Corpus work: 4fb396c3-e393-5845-92ed-182960bb4499
DOI: 10.25560/67985

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