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Article

Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease

12 Sept 2016

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified the ORM (yeast)-like protein isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk factor for childhood-onset asthma. OBJECTIVE: We sought to investigate in vivo the functional role of ORMDL3 in disease inception. METHODS: An Ormdl3-deficient mouse was generated and the role of ORMDL3 in the generation of allergic airways...

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PMID: 27623174
DOI: 10.1016/j.jaci.2016.07.033

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